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Neurotoxic effects of occupational solvent exposure

The aims of this project are:

  1. To conduct a cross-sectional survey of solvent exposures and neurological symptoms in 400 vehicle spray painters, and in a comparison group of 200 other blue collar workers with little or no exposure.
  2. To determine if there is a dose-dependent relationship between solvent exposure and neurological symptoms.
  3. To carry out a nested case-control study in the vehicle spray painters (75 with symptoms and 75 without symptoms) involving more detailed exposure measurements and neurobehavioural testing.
  4. For this nested subset, to assess whether the observed symptoms are consistent with acute effects and/or chronic effects of solvents.
  5. To assess whether acute and/or chronic effects are associated with peak or average exposure levels.
  6. To compare the results from the questionnaire and the neurobehavioural test battery to determine if they give consistent findings for the same neurologic function.

RELATED PUBLICATIONS

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Keer S. It’s academic—Solvent collisions. Safeguard, 2016; 157. link icon
Keer S, Glass B, Prezant B, McLean D, Pearce N, Harding E, Echeverria D, McGlothlin J, Babbage D, Douwes J. (2016) Neurobehavioural symptoms in collision repair workers – A cross-sectional survey. 25th Epidemiology in Occupational Health Conference 2016, 4-7 September, Barcelona, Spain. link icon
Keer S, Glass B, Prezant B, McLean D, Pearce N, Harding E, Echeverria D, McGlothlin J, Babbage D, Douwes J. Solvent neurotoxicity in vehicle collision repair workers in New Zealand. NeuroToxicology, 2016; 57: 223-229. link icon

July 2010

COLLABORATORS

  • Professor Janet Leathem
  • Massey University, NZ
  • Dr Duncan Babbage
  • Massey University, NZ
  • Dr Wendyl D'Souza
  • University of Melbourne, Australia

FUNDING

  • Health Research Council of New Zealand